Amyloid Fibrils (OC) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IF, IHC, IP, WB
Recommend Dilution	Dot Blot: 1/1000. A 1/1000 dilution of AP31731PU-N was sufficient for detection of Amyloid fibrils on PVDF membranes using transferred fibrils by colorimetric dot blot analysis using Goat anti-Rabbit IgG:HRP as the secondary antibody. Cited Applications: ELISA, Immunocytochemistry, Immunoprecipitation, Immunohistochemistry and Western Blot, Dot Blot.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fibrils prepared from Human Aß42 peptide.
Specificity	This antibody recognizes generic epitopes common to many Amyloid fibrils and fibrillar oligomers, but not prefibrilllar oligomers or natively folded proteins.
Formulation	PBS State: Purified State: Liquid purified IgG fraction Stabilizer: 50% Glycerol Preservative: 0.09% Sodium Azide
Concentration	lot specific
Purification	Protein A Chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Background	Amyloid monomeric proteins can sometimes oligomerize into destructive amyloid fibrils. Amyloidogenic conformations of non-disease related proteins can be created by partial protein misfolding or denaturation. Many degenerative diseases are known to be related to the accumulation of misfolded proteins as amyloid fibres (1, 2). These include the amyloid-β peptide plaques and tau neurofibrillary tangles in senile plaques of Alzheimer’s symptomology, the deposition of α-synuclein in the Lewy bodies of Parkinson's disease, and accumulation of polyglutamine-containing aggregates in Huntington’s disease (2, 3).
Synonyms	OC, Fibrils
Reference Data

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