Glycophorin A (GYPA) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, FC, WB
Recommend Dilution	Flow Cytometry. Western Blot. ELISA.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Human Glycophorin A transmembrane protein Donor: Rabbit serum
Specificity	Anti-human Glycophorin A (GpA) Polyclonal Antibody targets the human Glycophorin A protein. This polyclonal antibody recognizes various epitopes on the GpA protein. The 23 residue hydrophobic transmembrane domain has been shown to mediate non-covalent dimerization of the protein under conditions of SDS page (and in other detergents). We also sell a FITC conjugated version of this antibody (AP31671FC-N).
Formulation	PBS containing 0.02% sodium azide (NaN3) as preservative State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Affinity chromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	glycophorin A (MNS blood group)
Database Link	Entrez Gene 2993 Human UniProt ID P02724
Background	This 131 amino acid, 36 KDa, transmembrane sialoglycoprotein spans the membrane of erythrocytes once. GpA presents its N terminus at the extracellular surface of the human red blood cell, has a single transmembrane domain and an internal cytoplasmic C terminus. GpA contributes to the expression of blood group antigen M and N specificities, which work to prevent red blood cell aggregation in circulation. Studies show that GpA is expressed early on the cell surface during erythropoiesis as pluripotent stem cells are recruited to differentiate into erythrocytes. This makes GpA a useful marker for studying the developmental biology of hematopoietic progenitor cells.
Synonyms	Glycophorin-A, GPA, PAS-2, Sialoglycoprotein alpha, MN sialoglycoprotein
Reference Data
Protein Families	ES Cell Differentiation/IPS, Transmembrane
Protein Pathways	Hematopoietic cell lineage

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