MCL1 (121-139) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	Immunohistochemistry on Paraffin Sections: 1/25 - 1/100.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide corresponding to aa 121-139 of human Mcl-1
Specificity	This antibody reacts to Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 (MCL1).
Formulation	10 mM PBS, pH 7.4 containing 1% BSA as stabilizer and 0,09% sodium azide as preservative State: Purified State: Liquid purfied Ig fraction
Purification	Immunoaffinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C. DO NOT FREEZE!
Gene Name	myeloid cell leukemia 1
Database Link	Entrez Gene 4170 Human UniProt ID Q07820
Background	Myeloid cell leukimia-1 (Mcl-1) is a member of the Bcl-2 family of proteins that can act to promote cell survival. While the mechanism by which Mcl-1 inhibits apoptosis is not known, it is thought that it may heterodimerize and neutralize pro-apoptotic members of the Bcl-2 family such as Bim or Bak. Mcl-1 was originally identified in differentiating myeloid cells, but has since been shown to be expressed in multiple cell types. Mcl-1 is essential for embryogenesis (5) and for the development and maintenance of B and T lymphocytes in animals. Mcl-1 exists as at least two distinct isoforms designated Mcl-1L and Mcl-1S. In marked contrast to the larger isoform of Mcl-1, overexpression of Mcl-1S promotes cell death.
Synonyms	BCL2L3, Bcl-2-like protein 3, mcl1/EAT, EAT, r004
Reference Data
Protein Families	Druggable Genome, Transmembrane

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