GFAP Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	Immunohistochemistry on Paraffin Sections: 1/50.
Reactivity	Bovine, Chicken, Guinea Pig, Hamster, Human, Monkey, Mouse, Rat, Sheep
Host	Rabbit
Clonality	Polyclonal
Immunogen	GFAP isolated from Cow spinal cord
Specificity	This antibody recognizes Glial Fibrillary Acidic Protein (GFAP).
Formulation	10mM PBS, pH 7.4 State: Purified State: Liquid purfied IgG fraction Stabilizer: 0.2% BSA Preservative: 0.09% Sodium Azide
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C.
Gene Name	glial fibrillary acidic protein
Database Link	Entrez Gene 14580 MouseEntrez Gene 24387 RatEntrez Gene 712941 MonkeyEntrez Gene 2670 Human UniProt ID P14136
Background	Glial fibrillary acidic protein (GFAP) is an intermediate-filament (IF) protein that is highly specific for cells of astroglial lineage, although its tissue-specific role is speculative. GFAP has been located in rat kidney glomeruli and peritubular fibroblasts, leydig cells of testis, skin keratinocytes, osteocytes of bones, chondrocytes of epiglottis, bronchus, and stellate-shaped cells of the pancreas and liver. Its expression is essential for normal white matter architecture and blood-brain barrier integrity, and its absence leads to late-onset CNS dysmyelination. GFAP has also been shown to play a role in mitosis by adjusting the filament network present in the cell. During mitosis, there is an increase in the amount of phosphorylated GFAP, and a movement of this modified protein to the cleavage furrow.
Synonyms	Glial Fibrillary Acidic Protein
Reference Data
Protein Families	ES Cell Differentiation/IPS

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