Cox4i1 pSer58 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	Western blot: 1/1000.
Reactivity	Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Phosphopeptide corresponding to amino acid residues surrounding the phospho- Ser 58 of mouse COXIV protein
Specificity	Specific for the ~17k COXIV-1 protein phosphorylated at Ser58 . Immunolabeling is blocked by the phospho-peptide used as antigen but not by the corresponding dephospho-peptide.
Formulation	10 mM HEPES (pH 7.5), 150 mM NaCl, 100 μg BSA per ml and 50% glycerol State: Liquid Ig fraction
Purification	Affinity purification via sequential chromatography on phospho- and dephosphopeptide affinity columns
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	cytochrome c oxidase subunit IV isoform 1
Database Link	Entrez Gene 12857 Mouse UniProt ID P19783
Background	COX, also known as cytochrome c oxidase, has 12 subunits that make up the transmembrane mitochondrial protein. Subunit IV has two isoforms; COXIV-1 and COXIV-2 (Huttermann et al., 2001). COXIV-1 is ex pressed ubiquitously while COXIV-2 is highly expressed in adult lung and low levels in brain and heart (Huttermann et al., 2001). Phosphorylation of amino acid residue ser58 of the COXIV-1 protein is a PKA-dependent regulation of COX and plays an important role in metabolism and CREB cycle activation (Acin- Perez et al., 2011).
Synonyms	Cytochrome c oxidase polypeptide IV, COX IV-1, COX4I1, COX4
Reference Data

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