SYN1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IP, WB
Recommend Dilution	Western blot: 1/1000. Immunohistochemistry / immunoflourescence: 1:1000. Immunoprecipitation: 2 μl per 200 μg lysate.
Reactivity	Bovine, Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Native protein purified from bovine brain
Specificity	Specific for the ~78k synapsin I doublet in Western blots of rat brain extracts. Immunolabeling blocked by preadsorption of antibody with the protein used to generate the antibody.
Formulation	100 μl in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 μg BSA per ml and 50% glycerol State: Aff - Purified State: Liquid Ig fraction
Purification	Affinity purification using a column to which the native protein was coupled
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Database Link	Entrez Gene 281510 Bovine UniProt ID P17599
Background	Synapsin I plays a key role in synaptic plasticity in brain (Feng et al., 2002; Nayak et al., 1996). This effect is due in large part to the ability of the synapsins to regulate the availability of synaptic vesicles for release. In addition to its role in plasticity, the expression of synapsin I is a precise indicator of synapse formation (Moore and Bernstein, 1989; Stone et al., 1994). Thus, synapsin I immunocytochemistry provides a valuable tool for the study of synaptogenesis. The role of synapsin in synaptic plasticity and in synaptogensis is regulated by phosphorylation (Jovanovic et al., 2001; Kao et al., 2002).
Synonyms	Synapsin I, Brain protein 4.1, SYN1
Reference Data

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