CD163 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	ELISA. Western blot. Immunohistochemistry on Frozen Sections: 1/3000. Immunohistochemistry on Paraffin Sections: 1/300, Proteinase K pretreatment for antigen retrival is recommended. Suggested Positive Control:Human placenta.
Reactivity	Human, Porcine
Host	Rabbit
Clonality	Polyclonal
Immunogen	Partially purified CD163 from Human placenta. Antigen, epitope: Human CD163 migrates as a130kDa band in PAGE.
Specificity	This antibody detects CD163. Recognizes a membrane glycoprotein on Human/Porcine monocytes and macrophages which is expressed in intermediate and late inflammatory stages.
Formulation	Phosphate buffered saline pH 7.2 (PBS) State: Purified State: Liqiud purified Ig fraction Preservative: 0.09% Sodium Azide
Concentration	5.0 mg/ml
Purification	Affinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C.
Predicted Protein Size	130 kDa (PAGE)
Gene Name	CD163 molecule
Database Link	Entrez Gene 9332 Human UniProt ID Q86VB7
Background	CD163 is a scavenger re ceptor for the haemoglobin-haptoglobin complex, and is upregulated by glucocorticoids and IL-10. The extracellular portion of the receptor is regularly shed and can be found in the circulation. An important funct ion of CD163 seems to be in the adhesion of monocytes to activated endothelial cells. CD163-positive cells include skin histiocytes, Kupffer cells, spleen macrophages of the red pulp, and some thymus macrophages. The antigen is also found abundantly in human term placenta, and regularly in acute and chronic inflammatory lesions.
Synonyms	M130, Hemoglobin scavenger receptor, Macrophage marker
Reference Data

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