NFKB1 pSer337 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA
Recommend Dilution	ELISA: The antibody (approx. 1:100,000 - 1:400,000 diluted) can detect the serine 337 phosphorylated NF-κB p105/p50 peptide coated on ELISA plate at 100 ng/well.
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide derived from Serine337 phosphorylated NF-κB p105/p50, conjugated with KLH
Specificity	This antibody is reactive to the synthetic NF-κB p105/p50 peptide (QLRRKSpDLETSEP) on Mouse, human and other species with consensus serine 337 phosphorylated NF- κB p105/p50 peptide.
Formulation	0.01M PBS, pH 7.4 State: Azide Free State: Lyophilized Ig fraction
Reconstitution Method	Restore with double distilled water to adjust the final concentration to 1.00 mg/ml.
Purification	Protein G affinity
Conjugation	Unconjugated
Storage Condition	Store lyophilized at 2-8°C for 6 month or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing.
Gene Name	nuclear factor kappa B subunit 1
Database Link	Entrez Gene 4790 Human UniProt ID P19838
Background	NF-κB (nuclear factor kappa-light-chainenhancer of activated B cells) is a transcription factor that controls the transcription of many genes that are associated with immuno-response, antiapoptosis, neuroplasticity and memory. There are five NF-κB proteins in mammals: RelA (NF-κB-p65), RelB, c-Rel, NF-κB (NF-κB p105), and NF-κB2 (NF-κB p100). They form a variety of homodimers and heterodimers, each of which activates its own distinctive set of genes. P65 has been shown to be involved with DNA binding. The phosphorylation of p65 at Ser468 is inducible by TNF. Ser468 phosphorylation mediates p65 ubiquitination and the termination of related gene expression.
Synonyms	NFKB1, KBF1, EBP-1, EBP1, NF-kappa-B p50
Reference Data

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