BCL2 pThr56 Rabbit Polyclonal Antibody

CAT#: AP26416AF-N

BCL2 pThr56 rabbit polyclonal antibody, Azide Free



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CNY 5,621.00


货期*
4周

规格
    • 100 ug

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Specifications

Product Data
Applications ELISA
Recommend Dilution ELISA: Reacts with synthetic peptide (SQPGHTpPHPASR) coated plate.
Reactivity Human
Host Rabbit
Clonality Polyclonal
Immunogen A synthetic peptide derived from human Bcl-2, conjugated with KLH for immunization
Specificity This antibody reacts with Human and other species with consensus Bcl-2 sequence SQPGHTpPHPASR.
Formulation 0.01M PBS, pH 7.4
State: Azide Free
State: Lyophilized Ig fraction
Reconstitution Method Restore with water to adjust the final concentration to 1.00 mg/ml.
Purification Protein G affinity
Conjugation Unconjugated
Storage Condition Store lyophilized at 2-8°C for 6 month or at -20°C long term.
After reconstitution store the antibody undiluted at 2-8°C for one month
or (in aliquots) at -20°C long term.
Avoid repeated freezing and thawing.
Gene Name B-cell CLL/lymphoma 2
Background Bcl-2 is a 25kD inner mitochondrial membrane protein with anti-apoptotic function. It is believed that Bcl-2 suppresses apoptosis by inhibiting mitochondrial cytochrome C release, blocking caspase cascade and regulating mitochondrial calcium homeostasis. Bcl- 2 is identified from the study of B-cell lymphoma. About 90% of follicular lymphoma is caused by Bcl-2 overexpression resulted from the translocation of Bcl-2 gene from chromosome 18 to the immunoglobulin heavy chain enhancer on chromosome 14. Bcl-2 is also involved with other malignancies such as melanoma, breast cancer, prostate cancer and lung cancer. Bcl-2 Thr56 phosphorylation by p38 MAPK results in cytochrome C release. Mutation near Thr56 aborted Bcl-2 antiapoptotic function.
Synonyms BCL2, Bcl-2 alpha
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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