FPRL1 (FPR2) (C-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	A short peptide corresponding to the C-terminal amino acid sequence on FPRL1 was conjugated with KLH
Specificity	This antibody reacts with Human formyl peptide receptor-like 1.
Formulation	0.01M PBS, pH 7.2 State: Azide Free State: Lyophilized purified Ig fraction
Reconstitution Method	Restore with Double distilled water to adjust the final concentration to 1.00 mg/ml.
Conjugation	Unconjugated
Storage Condition	Store lyophilized at 2-8°C for 6 month or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing.
Gene Name	formyl peptide receptor 2
Database Link	Entrez Gene 2358 Human UniProt ID P25090
Background	Human formyl peptide receptor-like 1(FPRL1) is a G-protein coupled seven transmembrane receptor. The receptor can bind to the formyl peptides derived from the degradation of the cell wall of infected bacteria and host cells. FPRL1 expressed on the cell surface of neutrophils and other leukocytes mediates the chemotaxis of these cells toward infected site. It has been reported that acute phase protein SAA is also a ligand of FPRL1 and SAA can induce the secretion of IL-8 and TNF-α by neutrophil through FPRL1 signalling. FPRL1 has also been shown to mediate the chemotaxis of microglia by Abeta42 peptide and the internalization of Abeta42 peptide into cytoplasma of macrophage, indicating that FRPL1 may participate in the Abeta42 peptide elicited pathogenesis in Alzheimer’s disease.
Synonyms	N-formyl peptide receptor 2, FMLP-R-I, FPRH1, RFP, LXA4R
Reference Data

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