Occludin (OCLN) (358-504) Guinea Pig Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	Immunohistochemistry on Frozen Sections: The typical starting working dilution is 1/50. Immunoflourescence: The typical starting working dilution is 1/50. Western blot: The typical starting working dilution is 1/50.
Reactivity	Canine, Human, Mouse, Rat
Host	Guinea Pig
Clonality	Polyclonal
Immunogen	Recombinant Human Occludin (aa 358-504)
Specificity	The polyclonal antibody reacts with Occludin.
Formulation	PBS State: Purified State: Liquid 0.2 µm filtered Ig fraction Stabilizer: 0.1% BSA Preservative: 0.02% Sodium Azide
Concentration	lot specific
Purification	Protein A Chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C.
Gene Name	occludin
Database Link	Entrez Gene 100506658 Human UniProt ID Q16625
Background	Occludin is an integral membrane protein specifically associated with tight junctions. These specialized regions of the plasma membrane prevent the diffusion of dissolved molecules between adjacent epithelial cells, seal off body cavities such as intestine or stomach lumen and prevent the diffusion of membrane proteins and glycolipids between the apical and basolateral regions of the plasma membrane. Occludin is localized at tight junctions of both epithelial and endothelial cells and is highly expressed in kidney and has not been detected in testis. On the cytoplasmic surface of occludin, a domain within the C-terminal 150 residues has been shown to bind directly to the well-characterized tight junction protein zona occludens 1 (ZO-1).
Synonyms	OCLN
Reference Data

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