cIAP2 (BIRC3) (314-508) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Immunohistochemistry on Paraffin Sections: 10 µg/ml. Western Blot: 1/500 - 1/3000.
Reactivity	Bovine, Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant protein fragment containing a sequence corresponding to a region within amino acids 314 and 508 of Human cIAP2
Specificity	This antibody reacts to Baculoviral IAP Repeat-containing 3 (BIRC3) at aa 314-508.
Formulation	0.1M Tris-glycine, pH 7.0 containing 10% Glycerol and 0.01% Thimerosal State: Aff - Purified State: Liquid purfied Ig fraction
Concentration	lot specific
Purification	Immunoaffinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Gene Name	baculoviral IAP repeat containing 3
Database Link	Entrez Gene 330 Human UniProt ID Q13489
Background	Apoptosis inhibitor 2 (API2) is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. API2 inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. The amino acid sequence predicts three baculovirus IAP repeat domains and a ring finger domain. The names of API1 and API2 have been confusing. Suffice it to say that 'apoptosis inhibitor 2' is hiap-1 (inhibitor of apoptosis 1).
Synonyms	API2, MIHC, RNF49, C-IAP2, cIAP2, IAP homolog C, Apoptosis inhibitor 2, HIAP-1
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Apoptosis, Focal adhesion, NOD-like receptor signaling pathway, Pathways in cancer, Small cell lung cancer, Ubiquitin mediated proteolysis

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