CARD11 (18-238) Rabbit Polyclonal Antibody

CAT#: AP23584PU-N

CARD11 (18-238) rabbit polyclonal antibody, Aff - Purified



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CNY 5,511.00


货期*
5周

规格
    • 50 ul

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Specifications

Product Data
Applications IHC, WB
Recommend Dilution Immunohistochemistry on Paraffin Sections: 10 µg/ml.
Western Blot: 1/500 - 1/3000.
Reactivity Bovine, Human, Mouse
Host Rabbit
Clonality Polyclonal
Immunogen Recombinant protein fragment containing a sequence corresponding to a region within amino acids 18 and 238 of Human CARD11
Specificity This antibody reacts to Caspase Recruitment Domain Family, Member 11 (CARD11).
Formulation 0.1 M Tris-glycine, pH 7.0 containing 10% Glycerol as stabilizer and 0.01% Thimerosal as preservative
State: Aff - Purified
State: Liquid purfied Ig fraction
Concentration lot specific
Purification Immunoaffinity Chromatography
Conjugation Unconjugated
Storage Condition Store the antibody at -20°C.
Avoid repeated freezing and thawing.
Gene Name caspase recruitment domain family member 11
Background CARMA proteins belong to the membrane-associated guanylate kinase-like (MAGUK) family of proteins that can function as molecular scaffolds that assist assembly of signal transduction molecules. CARMA1, CARMA2, and CARMA3 share high degrees of sequence and functional homology, but their tissue-specific distribution suggests that they serve distinct biological functions in different cell types. Both CARMA1 and CARMA3 associate with NEMO, the regulatory subunit of the IkK complex, thereby regulating activation of the NF-kB transcription factor. Also, gene inactivation studies showed a complete block in T and B cell immunity as well as an impaired response to LPS, indicating that CARMA1 is a critical regulator in both the adaptive and innate immune systems.
Synonyms BIMP3; CARMA1; MGC133069
Reference Data
Protein Families Druggable Genome
Protein Pathways B cell receptor signaling pathway, T cell receptor signaling pathway
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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