cyclic GMP Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	R
Recommend Dilution	RIA Antigen binding capacity: Dilutions 1/2000 bound 45-50% of the labelled (radioactive) nucleotide.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Succinyl cGMP- Human Serum Albumin conjugate
Specificity	Cross-reactivity at 50% displacement: cAMP < 0.0005% GTP < 0.00001% ATP < 0.00001%
Formulation	State: Serum State: Lyophilized Serum
Reconstitution Method	Restore in aqua bidest to initial volume.
Conjugation	Unconjugated
Storage Condition	Store lyophilized at 2-8°C and reconstituted at -20°C. Avoid repeated freezing and thawing.
Background	Cyclic guanosine monophosphate (cGMP) serves as a second messenger in a manner similar to that observed with cAMP. Peptide hormones, such as the natriuretic factors, activate receptors that are associated with membrane-bound guanylate cyclase (GC). Receptor activation of GC leads to the conversion of GTP to cGMP. Nitric oxide (NO) also stimulates cGMP production by activating soluble GC, perhaps by binding to the heme moiety of the enzyme. Similar to cAMP, cGMP mediates most of its intracellular effects through the activation of specific cGMP dependent protein kinases (PKG).
Synonyms	cGMP, cyclic guanosine monophosphate
Reference Data

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