Col17a1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC
Recommend Dilution	Immunofluorescence. Immunohistochemistry on Cryosections.
Reactivity	Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Mouse COL17A
Specificity	Recognizes Mouse Collagen type XVII. Other species not tested.
Formulation	PBS pH 7.4 State: Purified State: Lyophilized purified IgG fraction from Serum
Reconstitution Method	Restore in aqua bidest to initial volume
Purification	Protein G Chromatography
Conjugation	Unconjugated
Storage Condition	Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing.
Gene Name	collagen, type XVII, alpha 1
Database Link	Entrez Gene 12821 Mouse UniProt ID Q07563
Background	Unlike most collagens, collagen XVII is a transmembrane protein. Collagen XVII is a structural component of hemidesmosomes, multiprotein complexes at the dermal epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane. Mutations in the gene coding for collagen XVII are associated with both generalized atrophic benign and junctional epidermolysis bullosa. Two homotrimeric forms of type XVII collagen exist. The full length form is the transmembrane protein. A soluble form, referred to as either ectodomain or LAD 1, is generated by proteolytic processing of the full length form. Two transcript variants, one resulting from alternative splicing in the 3' UTR, have been identified for this gene.
Synonyms	COL17A1, BP180, BPAG2, Bullous pemphigoid antigen 2, LAD-1, LABD97
Reference Data

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