Phospholamban (PLN) (N-term) Rabbit Polyclonal Antibody

CAT#: AP23398PU-N

Phospholamban (PLN) (N-term) rabbit polyclonal antibody, Aff - Purified



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CNY 5,599.00


货期*
5周

规格
    • 100 ug

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Specifications

Product Data
Applications WB
Recommend Dilution Western blot: 1 μg/ml.
Reactivity Human, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Immunogen A synthetic peptide corresponding to a sequence at the N-terminal of human Phospholamban
Specificity This antibody detects Phospholamban (N-term). No cross reactivity with other proteins.
Formulation 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3
State: Aff - Purified
State: Lyophilized Ig fraction
Reconstitution Method 0.2ml of distilled water will yield a concentration of 500μg/ml.
Purification Immunogen affinity purified
Conjugation Unconjugated
Storage Condition Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Gene Name phospholamban
Background Phospholamban is a 52 amino acid integral membrane protein that regulates the Ca2+ pump in cardiac muscle and skeletal muscle cells. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. Phospholamban is also expressed in slow-twitch skeletal muscle and some smooth muscle cells. McTiernan et al. (1999) observed that human ventricle and quadriceps displayed high levels of phospholamban transcripts and proteins, with markedly lower expression observed in smooth muscles, while the right atrium also expressed low levels of phospholamban. The structure of the human phospholamban gene closely resembles that reported for chicken, rabbit, rat, and mouse. Comparison of the human to other mammalian phospholamban genes indicated a marked conservation of sequence for at least 217 bp upstream of the transcription start site.
Synonyms Cardiac phospholamban, PLB, PLN
Reference Data
Protein Families Transmembrane
Protein Pathways Calcium signaling pathway, Dilated cardiomyopathy
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