Secretogranin 3 (SCG3) (C-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Western blot: At 1-2μg/ml with the appropriate system to detect SCG3 in cells and tissues. Immunohistochemistry on paraffin sections: At 0.5-1μg/ml to detect SCG3 in formalin fixed and paraffin embedded tissues. Immunohistochemistry on frozen sections: At 0.5-1μg/ml to detect SCG3 in formalin or acetone fixed tissues.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a sequence near the C-terminal of human SCG3
Specificity	This antibody detects Secretogranin-3 (SCG3) at C-term. No cross reactivity with other proteins.
Formulation	5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3 State: Aff - Purified State: Lyophilized Ig fraction
Reconstitution Method	0.2ml of distilled water will yield a concentration of 500μg/ml.
Purification	Immunogen affinity purified
Conjugation	Unconjugated
Storage Condition	Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Gene Name	secretogranin III
Database Link	Entrez Gene 20255 MouseEntrez Gene 116635 RatEntrez Gene 29106 Human UniProt ID Q8WXD2
Background	SCG3 (secretogranin Ⅲ) is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Genetic variations in the SCG3 gene may influence the risk of obesity through possible regulation of hypothalamic neuropeptide secretion. SCG3 was the only gene within a haplotype block that contained rs3764220. SCG3 mRNA and immunoreactivity were detected in the paraventricular nucleus, lateral hypothalamic area, and arcuate nucleus, and the protein coexisted with orexin, melanin-concentrating hormone, neuropeptide Y, and proopiomelanocortin. SCG3 formed a granule-like structure together with these neuropeptides.
Synonyms	Secretogranin III, Sg-III, SgIII
Reference Data
Protein Families	Druggable Genome, Secreted Protein

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