NOTCH1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	Western blot: 1μg/ml.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a sequence at the middle region of human NOTCH1
Specificity	This antibody detects NOTCH1 (middle). No cross reactivity with other proteins.
Formulation	State: Aff - Purified State: Lyophilized Ig fraction
Reconstitution Method	0.2 ml of distilled water will yield a concentration of 500 μg/ml
Purification	Immunogen affinity purified
Conjugation	Unconjugated
Storage Condition	Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Gene Name	notch 1
Database Link	Entrez Gene 4851 Human UniProt ID P46531
Background	Notch proteins are single-pass transmembrane receptors that regulate cell fate decisions during development. The Notch family includes 4 receptors, NOTCH1, NOTCH2, NOTCH3, and NOTCH4, whose ligands include JAG1, JAG2, DLL1), DLL3, and DLL4. Notch homolog 1, translocation-associated (NOTCH1), is a human gene encoding a single-pass transmembrane receptor. It functions as a receptor for membrane bound ligands, and may play multiple roles during development. NOTCH1 may normally coordinates the process of somitogenesis,1 and the activated Notch 1 and Notch 3 promote ifferentiation of progenitor cells into astroglia.
Synonyms	Notch 1, hN1, TAN1
Reference Data
Protein Families	Adult stem cells, Cancer stem cells, Druggable Genome, ES Cell Differentiation/IPS, Stem cell relevant signaling - DSL/Notch pathway
Protein Pathways	Dorso-ventral axis formation, Notch signaling pathway, Prion diseases

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.