MMP14 (C-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Western blot: At 0.5-1μg/ml with the appropriate system to detect MMP14 in cells and tissues. Immunohistochemistry on paraffin sections: At 1-2 μg/ml to detect MMP14 in formalin fixed and paraffin embedded tissues. Immunohistochemistry on frozen sections: At 1-2 μg/ml to detect MMP14 in formalin or acetone fixed tissues.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide mapping at the C-terminal of human MMP14
Specificity	This antibody detects MMP-14 (C-term).
Formulation	5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3 State: Aff - Purified State: Lyophilized Ig fraction
Reconstitution Method	0.2ml of distilled water will yield a concentration of 500μg/ml.
Purification	Immunogen affinity purified
Conjugation	Unconjugated
Storage Condition	Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Gene Name	matrix metallopeptidase 14
Database Link	Entrez Gene 17387 MouseEntrez Gene 81707 RatEntrez Gene 4323 Human UniProt ID P50281
Background	Matrix metalloproteinases (MMPs) are Zn(2+)-binding endopeptidases that degrade various components of the extracellular matrix (ECM). The MMPs are enzymes implicated in normal and pathologic tissue remodeling processes, wound healing, angiogenesis, and tumor invasion. MMPs have different substrate specificities and are encoded by different genes. membrane-type matrix metalloproteinase (MMP14) may be an activator of pro-gelatinase A (MMP2) and is expressed in fibroblast cells during both wound healing and human cancer progression. Survivin, MMP2, MMP9, and MMP14 mRNA expression levels in clinically aggressive pigmented lesions were significantly higher than those in normal eutopic endometrium, and survivin gene expression in pigmented lesions was also higher than that in nonpigmented lesions (P less than 0.05). There was a close correlation between survivin and MMP2, MMP9, and MMP14 gene expression levels in 63 endometriotic tissues examined (P less than 0.01).
Synonyms	Matrix metalloproteinase-14, MMP14, MMP-X1, Membrane-type-1 matrix metalloproteinase
Reference Data
Protein Families	Druggable Genome, Protease, Transmembrane
Protein Pathways	GnRH signaling pathway

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