Myeloperoxidase (MPO) (C-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	Western Blot: Use at 0.1-0.5 ?g/ml with the appropriate system to detect MPO in cells and tissues. Immunohistochemistry on Paraffin Sections: Use at 0.5-1 µg/ml to detect MPO in formalin fixed and paraffin embedded tissues. By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining of formalin/paraffin sections. Immunocytochemistry.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a sequence mapping at the C-terminal of Human MPO
Specificity	This antibody detects Myeloperoxidase at C-term. No cross reactivity with other proteins.
Formulation	5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg Sodium Azide State: Aff - Purified State: Lyophilized purified Ig fraction
Reconstitution Method	0.2 ml of distilled water will yield a concentration of 0.5 mg/ml.
Concentration	0.5 mg/ml (after reconstitution)
Purification	Immunogen Affinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing.
Gene Name	myeloperoxidase
Database Link	Entrez Gene 17523 MouseEntrez Gene 303413 RatEntrez Gene 4353 Human UniProt ID P05164
Background	Myeloperoxidase (MPO) is a mammalian phagocyte hemoprotein thought to primarily mediate host defense reactions. It is abundantly expressed in neutrophils and secreted during their activation. Myeloperoxidase is part of the host defense system of human polymorphonuclear leukocytes, responsible for microbicidal activity against a wide range of organisms. It is located in the nucleus as well as in the cytoplasm. Intranuclear MPO may help to protect DNA against damage resulting from oxygen radicals produced during myeloid cell maturation and function.
Synonyms	MPO
Reference Data
Protein Families	Druggable Genome

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