SynCAM (CADM1) Goat Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, WB
Recommend Dilution	Peptide ELISA: 1/16000 (Detection limit). Western blot: 0.1-0.3 µg/ml. Approx 42kDa band observed in Mouse Heart lysates (Calculated MW of 45.8kDa according to Mouse NP_001020771.1).
Reactivity	Bovine, Canine, Human, Mouse, Rat
Host	Goat
Clonality	Polyclonal
Immunogen	Peptide with sequence from the internal region of the protein sequence according to NP_055148.3; NP_001091987.1.
Specificity	This antibody is expected to recognize both reported isoforms (NP_055148.3 and NP_001091987.1).
Formulation	Tris saline, pH 7.3 containing 0.02% Sodium Azide as preservative and 0.5% BSA as stabilizer. State: Aff - Purified State: Liquid purified Ig fraction.
Concentration	lot specific
Purification	Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	cell adhesion molecule 1
Database Link	Entrez Gene 54725 MouseEntrez Gene 363058 RatEntrez Gene 23705 Human UniProt ID Q9BY67
Background	Cell Adhesion Molecules (CAMs) are proteins located on the cell surface involved with binding with other cells or with the extracellular matrix. SynCAM belongs to immunoglobulin superfamily 4 and is involved in cell-cell adhesion. Loss of SynCAM is common in a number of cancers including lung, breast, prostate and meningioma. This loss of SynCAM in advanced stage cancers suggests a role in tumor invasion and/or metastasis. Also recent studies have shown that SynCAM suppresses induction of EMT (epithelial mesenchymal transition) via regulation of Rho GTPases.
Synonyms	IGSF4, IGSF4A, NECL2, TSLC1, NECL-2, SgIgSF, TSLC-1
Reference Data
Protein Families	Transmembrane
Protein Pathways	Cell adhesion molecules (CAMs)

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