POLR3A Rabbit Polyclonal Antibody

CAT#: AP21068PU-S

POLR3A rabbit polyclonal antibody, Aff - Purified



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CNY 800.00


货期*
2周

规格
    • 25 ul

Product images

Specifications

Product Data
Applications IHC, WB
Recommend Dilution Western blot: 1/500-1/1000.
Immunohistochemistry on Paraffin Sections: 1/50-1/200.
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Specificity This antibody detects endogenous levels of POLR3A protein.
(region surrounding Pro68)
Formulation Phosphate buffered saline (PBS), pH~7.2
State: Aff - Purified
State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE)
Preservative: 0.05% Sodium Azide
Concentration 1.0 mg/ml
Purification Affinity Chromatography using epitope-specific immunogen
Conjugation Unconjugated
Storage Condition Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Predicted Protein Size ~ 156 kDa
Gene Name polymerase (RNA) III subunit A
Background RNA polymerase III (Pol III) is a multi-subunit complex responsible for catalyzing the transcription of DNA into RNA. POLR3A (polymerase (RNA) III (DNA directed) polypeptide
A), also known as RPC1 or RPC155, is a 1,390 amino acid protein that localizes to the nucleus and belongs to the RNA polymerase β chain family. Existing as the largest and catalytic core component of Pol III, POLR3A functions as a DNA-dependent RNA polymerase that catalyzes the conversion of a nucleoside triphosphate into a diphosphate, thereby transcribing DNA into RNA. The gene encoding POLR3A maps to human chromosome 10, which houses over 1,200 genes and comprises nearly 4.5% of the human genome. Defects in some of the genes that map to chromosome 10 are associated with Charcot-Marie Tooth disease, Jackson-Weiss syndrome, Usher syndrome, nonsyndromatic deafness, Wolmans syndrome, Cowden syndrome, multiple endocrine neoplasia type 2 and porphyria.
Synonyms RNA polymerase III subunit C1, RPC1, RPC155
Reference Data
Protein Families Transcription Factors
Protein Pathways Cytosolic DNA-sensing pathway, Metabolic pathways, Purine metabolism, Pyrimidine metabolism, RNA polymerase
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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