SLC22A6 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Western blot: 1/500-1/1000. Immunohistochemistry on Paraffin Sections: 1/50-1/200.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to amino acids 271-320 of Human OAT1.
Specificity	This antibody detects endogenous levels of OAT1 protein. (region surrounding Leu304).
Formulation	Phosphate buffered saline (PBS), pH 7.2 State: Aff - Purified State: Liquid purified Ig fraction Preservative: 15 mM Sodium Azide
Concentration	1.0 mg/ml
Purification	Affinity Chromatography (> 95% (by SDS-PAGE)
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	~ 65 kDa
Gene Name	solute carrier family 22 member 6
Database Link	Entrez Gene 18399 MouseEntrez Gene 29509 RatEntrez Gene 9356 Human UniProt ID Q4U2R8
Background	OAT1 (organic anion transporter 1), a 563 amino acid protein, and OAT3 (organic anion transporter 3), a 542 amino acid protein, are two members of the OAT family and are highly expressed in kidneys. Localized specifically to the basolateral membrane, OAT1 and OAT3 are involved in the elimination of toxic organic anions, such as benzylpenicillin and cimetidine, from proximal renal tubules. Via their ability to remove anions from renal tissues, OAT1 and OAT3 are able to regulate the amount of toxins within the kidneys. Additionally, OAT1 functions as an organic anion exchanger that couples the uptake of one organic anion molecule with the efflux of one endogenous dicarboxylic acid molecule, such as ketoglutarate.
Synonyms	Organic anion transporter 1, ROAT, PAHT
Reference Data
Protein Families	Transmembrane

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