Inhibin beta C chain (INHBC) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Western blot: 1/500 - 1/1000. Immunohistochemistry on paraffin sections: 1/50 - 1/200.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide, corresponding to amino acids 100-150 of Human Inhibin β-C.
Specificity	This antibody detects endogenous levels of Inhibin beta-C protein. (region surrounding Val129)
Formulation	Phosphate buffered saline (PBS), pH 7.2. State: Aff - Purified State: Liquid purified Ig fraction (> 95% by SDS-PAGE) Preservative: 0.05% sodium azide
Concentration	1.0 mg/ml
Purification	Immunoaffinity chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	~ 30 kDa
Gene Name	inhibin beta C subunit
Database Link	Entrez Gene 3626 Human UniProt ID P55103
Background	The TGFbeta superfamily is composed of numerous growth and differentiation factors, including transforming growth factor beta (TGFbeta) 1, 2 and 3; growth/differentiation factor (GDF) 1 through 8; Mullerian inhibiting substance (MIS); bone morphogenic protein (BMP) 2 through 8; glial cell linederived neurotrophic factor (GDNF); inhibins (alpha, beta-A, beta-B and beta-C), Lefty and Nodal. Members of the TGFbeta superfamily are involved in embryonic development and adult tissue homeostasis. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins and activins are involved in regulating a number of functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth depending on their subunit composition. Activins oppose the funtions of inhibins. Inhibins are predominantly expressed in liver, uterus and ovary tissue, but also in benign prostatic hyperplasia. Inhibin A, a dimer of alpha and beta-A, and inhibin B, a dimer of alpha and beta-B, have been shown to inhibit the secretion of follicle stimulating hormone. Inhibin beta-C forms a homodimer and its expression is predominant in adult liver and in benign prostatic hyperplasia.
Synonyms	Activin beta-C chain, Activin C
Reference Data
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	Cytokine-cytokine receptor interaction, TGF-beta signaling pathway

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