COX2 (PTGS2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	Western blot: 1/500-1/1000. Immunohistochemistry on paraffin sections: 1/50-1/200. Immunofluorescence: 1/50-1/200.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Specificity	This antibody antibody detects endogenous levels of Cox2/PGHS2 protein.
Formulation	Phosphate buffered saline (PBS), pH~7.2 containing 0.05% Sodium Azide as preservative. State: Aff - Purified State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE) .
Concentration	1.0 mg/ml
Purification	Affinity Chromatography using epitope-specific immunogen.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	~ 74 kDa
Gene Name	prostaglandin-endoperoxide synthase 2
Database Link	Entrez Gene 5743 Human UniProt ID P35354
Background	Prostaglandins are a diverse group of autocrine and paracrine hormones that mediate many cellular and physiologic processes. Prostaglandin H2 (PGH2) is an intermediate in formation of the prostaglandins. Two prostaglandin synthases that catalyze the formation of PGH2 from arachidonic acid (AA) are cyclooxygenase-1 and cyclooxygenase-2. Cyclooxygenase-2, or Cox-2, is efficiently induced in migratory cells responding to pro-inflammatory stimuli and is considered to be an important mediator of inflammation. An alternative form of the protein, designated Cox-1, is constitutively expressed in most tissues and is thought to serve in general “housekeeping” functions. Both enzymes are targets for the nonsteroidal therapeutic anti-inflammatorydrugs, NSAIDs.
Synonyms	Cyclooxygenase-2, PTGS2, COX2, PHS II, PGH synthase 2, PGHS-2, PGHS2
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Arachidonic acid metabolism, Pathways in cancer, Small cell lung cancer, VEGF signaling pathway

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