DERL1 (C-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	FC, IHC, WB
Recommend Dilution	ELISA: 1/1,000. Western blotting: 1/100-1/500.  Flow Cytometry: 1/10-1/50.  Immunohistochemistry on Paraffin Sections: 1:50~100
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	KLH conjugated synthetic peptide between 222~251 amino acids from the C-term region of Human Derlin-1
Specificity	This antibody recognizes Human and Mouse Derlin-1 at C-term.  Other species not tested.
Formulation	PBS containing 0.09% (W/V) Sodium Azide as preservative State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Protein A column, followed by peptide affinity purification
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	derlin 1
Database Link	Entrez Gene 79139 Human UniProt ID Q9BUN8
Background	Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. DERL1 may act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. It may mediate the interaction between VCP and the degradation substrate. In case of infection by cytomegaloviruses, it plays a central role in the export from the ER and subsequent degradation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Also participates in the degradation process of misfolded cytomegalovirus US2 protein.
Synonyms	Der1-like protein 1, DERL1, DER1, DERtrin-1
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Amyotrophic lateral sclerosis (ALS)

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