LTA (Center) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	FC, IHC, WB
Recommend Dilution	ELISA: 1/1000. Western blotting: ~1/1000. Flow Cytometry: 1/10-1/50. Immunohistochemistry on Paraffin Sections: 1/50-1/100.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	KLH conjugated synthetic peptide between 46-72 amino acids from the Central region of Human LTA.
Specificity	This antibody recognizes Human TNF-beta / Lymphotoxin-alpha. Other species not tested.
Formulation	PBS State: Liquid purified Ig fraction Preservative: 0.09% (W/V) Sodium Azide
Concentration	lot specific
Purification	Peptide Affinity Chromatography on Protein A
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	22297 Da
Gene Name	lymphotoxin alpha
Database Link	Entrez Gene 4049 Human UniProt ID P01374
Background	LTA, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis.
Synonyms	TNFB, TNFSF1, LTA, LT-alpha
Reference Data
Protein Families	Druggable Genome, Secreted Protein, Transmembrane
Protein Pathways	Antigen processing and presentation, Cytokine-cytokine receptor interaction, Type I diabetes mellitus

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