FKBP52 (FKBP4) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	FC, WB
Recommend Dilution	ELISA: 1/1,000.   Western blot: 1/1000.  Flow Cytometry: 1/10-1/50.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	KLH conjugated synthetic peptide between 186-216 amino acids from the Central region of Human FKBP4.
Specificity	This antibody detects FKBP4 at Center.
Formulation	PBS with 0.09% (W/V) Sodium Azide State: Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	51805 Da
Gene Name	FK506 binding protein 4
Database Link	Entrez Gene 2288 Human UniProt ID Q02790
Background	FKBP4 is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy.
Synonyms	FK506-binding protein 4, FKBP52 protein, FKBP59, p59 protein
Reference Data
Protein Families	Druggable Genome

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