Endothelin B Receptor (EDNRB) (C-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	Western blot: 1:50 - 1:100. ELISA: 1:1,000.
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	KLH conjugated synthetic peptide selected from the C-terminal region of human EDNRB
Specificity	This antibody detects Endothelin B receptor at C-term.
Formulation	PBS with 0.29% (W/V) sodium azide State: Liquid IG fraction
Concentration	lot specific
Purification	Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
Conjugation	Unconjugated
Storage Condition	Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Gene Name	endothelin receptor type B
Database Link	Entrez Gene 13618 MouseEntrez Gene 1910 Human UniProt ID P24530
Background	EDNRB is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene.
Synonyms	ET-BR, ET-B, EDNRB, ETRB, ETB, ETBR, HSCR, WS4A, ABCDS, HSCR2
Note	Molecular weight: 49644 Da
Reference Data
Protein Families	Druggable Genome, GPCR, Transmembrane
Protein Pathways	Calcium signaling pathway, Melanogenesis, Neuroactive ligand-receptor interaction

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