CTRP1 (C1QTNF1) (N-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	Western blot: 1:50 - 1:100. ELISA: 1:1,000.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	KLH conjugated synthetic peptide selected from the N-terminal region of human C1QTNF1
Specificity	This antibody detects C1QTNF1 at N-term.
Formulation	PBS with 0.09% (W/V) sodium azide State: Liquid Ig fraction
Concentration	lot specific
Purification	Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS
Conjugation	Unconjugated
Storage Condition	Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Gene Name	C1q and tumor necrosis factor related protein 1
Database Link	Entrez Gene 114897 Human UniProt ID Q9BXJ1
Background	CTRPs (C1q/tumor necrosis factor-{alpha}-related proteins) are a widely expressed and highly conserved family of adiponectin paralogs. CTRP1 consists of an N-terminal signal peptide sequence followed by a variable region, a collagen repeat domain, and a C-terminal globular domain. Unlike adiponectin, which is expressed exclusively by differentiated adipocytes, the CTRPs are expressed in a wide variety of tissues. These proteins are thought to act mainly on liver and muscle tissue to control glucose and lipid metabolism. An analysis of the crystal structure of adiponectin revealed a structural and evolutionary link between TNF and CTRPs, suggesting that these proteins arose from a common ancestral innate immunity gene. CTRP1 expression may be associated with a low-grade chronic inflammation status in adipose tissues.
Synonyms	CTRP1, GIP
Note	Molecular weight: 31743 Da
Reference Data
Protein Families	Druggable Genome, Secreted Protein, Transmembrane

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