Munc 13 4 (UNC13D) Goat Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	ELISA: 1/128000. Western Blot: 1 - 3 µg/ml. Immunohistochemistry on paraffin sections: 2.5 µg/ml.
Reactivity	Canine, Human, Mouse, Rat
Host	Goat
Clonality	Polyclonal
Immunogen	Peptide with sequence C-ETQKHKKDLHPLFD, from the internal region of the protein sequence
Specificity	This antibody reacts to Munc13-4 / UNC13D.
Formulation	Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin State: Aff - Purified State: Liquid purified Ig
Concentration	lot specific
Purification	Affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	unc-13 homolog D
Database Link	Entrez Gene 201294 Human UniProt ID Q70J99
Background	Secretion of the contents of cytolytic granules at the immunologic synapse is a highly regulated process essential for lymphocyte cytotoxicity. This process requires the rapid transfer of perforin containing lytic granules to the target cell interface, followed by their docking and fusion with the plasma membrane. Munc 13-4 localises with cytotoxic granules at the immunologic synapse. Munc 13-4 is essential for the priming step of cytolytic granule secretion preceding vesicle membrane fusion. There are two named isoforms.
Synonyms	Protein unc-13 homolog D, Munc13-4
Reference Data

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