RAF1 pTyr341 Rabbit Polyclonal Antibody

CAT#: AP12891PU-N

RAF1 pTyr341 rabbit polyclonal antibody, Aff - Purified



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CNY 6,314.00


货期*
5周

规格
    • 400 ul

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Specifications

Product Data
Recommend Dilution ELISA: 1/1,000.
Dot Blot: 1/500.
Reactivity Human
Host Rabbit
Clonality Polyclonal
Immunogen This antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S341 of human RAF1.
Specificity This antibody detects RAF1 pTyr341.
Predicted to cross react with Mouse (100% Antigen Homology).
Formulation PBS with 0.09% (W/V) Sodium Azide as preservative.
State: Aff - Purified
State: Liquid purified Ig fraction.
Concentration lot specific
Purification Affinity purification in a 2-step procedure with the control and phosphorylated peptides. The phospho-specific antibody is eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Conjugation Unconjugated
Storage Condition Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Gene Name Raf-1 proto-oncogene, serine/threonine kinase
Background Raf-1 is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated Raf-1 can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2 which in turn phosphorylate to activate the serine/threonine specific protein kinases ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration.
Synonyms C-RAF, Raf-1, cRaf
Note Molecular weight: 73052 Da
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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