Imipramine Sheep Polyclonal Antibody

Specifications

Product Data
Applications	ELISA
Recommend Dilution	ELISA: 0.625 µg/ml.
Host	Sheep
Clonality	Polyclonal
Immunogen	Imipramine-BTG
Specificity	This antibody recognizes Imipramine, a tricyclic antidepressant (TCA).
Formulation	20mM Phosphate, 150mM Sodium Chloride, pH 7.2 containing 0.09% Sodium Azide as preservative. State: Ig Fraction State: Liquid Ig fraction prepared by Caprylic Acid and Ammonium Sulphate precipitation procedures.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Background	Tricyclic antidepressants contain a characteristic three ringed nucleus structure. They act primarily as serotoninnorepinephrine reuptake inhibitors. Tricyclic antidepressants are mainly used as antidepressants, but have also been for the treatment of anxiety disorders and attention hyperactivity disorder and as an adjunct to certain analgesics to treat chronic pain. In many treatments they have been replaced by other compounds with fewer sideeffects. Tricyclic antidepressants are not considered addictive and have a low abuse potential, but suddenly discontinuing treatment may results in discontinuation syndrome and overdose is a main cause of death from prescription drugs. They have significant cardiovascular and neurological toxicity. Monitoring of TCA levels can help determine toxicity, monitor compliance and establish individual target concentrations. Imipramine is a member of the family of tricyclic antidepressants. Its clinical effect is hypothesized as being due to potentiation of adrenergic synapses by blocking uptake of norepinephrine at nerve endings. Imipramine is a very powerful antidepressant and is converted to desipramine in the body.
Synonyms	Antideprin, Berkomine, Cristalia, Melipramine, Prazepine, Sermonil, Tricyclic Antidepressant
Reference Data

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