Gestrinone Sheep Polyclonal Antibody

Specifications

Product Data
Applications	ELISA
Recommend Dilution	ELISA: 0.039 µg/ml.
Host	Sheep
Clonality	Polyclonal
Immunogen	Gestrinone-BTG
Specificity	This antibody recognizes Gestrinone.
Formulation	20mM Phosphate, 150mM Sodium Chloride, pH 7.2 containing 0.09% Sodium Azide as preservative. State: Ig Fraction State: Liquid Ig fraction prepared by Caprylic Acid and Ammonium Sulphate precipitation procedures.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Background	Endometriosis is common disease characterized by the presence of endometrial tissue outside the uterus which affects approximately 10% of premenopausal women. Gestrinone is a synthetic steroid used occasionally to treat endometriosis.(1) It acts centrally on the hypothalamic-pituitary system to suppress release of lutenizing hormone (LH) and follicle-stimulating hormone (FSH), thus reducing estrogen synthesis.(1) It also binds to androgen (AR), progesterone (PR), and estrogen (ER) receptors in the human endometrial tissue but not to steroid hormone binding globulin or corticord-binding globulin.(2) Gestrinone binds to AR and PR with EC50 values of approximately 20 and 30 nM, respectively.(3) These values reflect approximately 5-6 fold lower affinity than testosterone and progesterone, the natural AR and PR ligands, for these receptors.(3)
Synonyms	Dimetriose, Dimetrose, Nemestran, Gestrigone, Tridomose, Ethylnorgestrienone, Gestrinonum
Reference Data

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