Zbtb7b Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, WB
Recommend Dilution	ELISA: 1:2,500 - 1:10,000. Western blot: 1:500 - 1:3,000.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to an internal sequence of mouse cKrox protein
Specificity	This antibody is directed against mouse cKrox.
Formulation	0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2, 0.01% (w/v) Sodium Azide State: Serum State: Lyophilized delipidated and defibrinated antiserum
Reconstitution Method	Reconstitute with 0.1 ml of deionized water.
Conjugation	Unconjugated
Storage Condition	Store vial at 2-8° C prior to opening. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Dilute only prior to immediate use.
Gene Name	zinc finger and BTB domain containing 7B
Database Link	Entrez Gene 22724 Mouse UniProt ID Q64321
Background	cKrox (also known as Zfp67 or ThPOK) functions as a transcription regulator that acts as a key modulator of lineage commitment for immature T-cell precursors. cKrox is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. cKrox is a known transcriptional repressor of the collagen COL1A1 and COL1A2 genes and may also function as a repressor of fibronectin and possibly other extracellular matrix genes. cKrox is located within the nucleus and is expressed in multiple tissues and organs including skin, thymus and peripheral T-cells.
Synonyms	ZFP67, Zfp-67, ZBTB15, ZBT-15, Thpok, Th-POK, cKrox, c-Krox
Reference Data

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