CIITA Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IP
Recommend Dilution	Immunoprecipitation.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Peptide corresponding to a region near the N-terminal end of the human CIITA gene conjugated to Keyhole Limpet Hemocyanin (KLH)
Specificity	This antibody detetcs CIITA.
Formulation	0.01% (w/v) Sodium Azide, containing no stabilizer. State: Serum State: Liquid sterile filtered antibody, prepared from monospecific antiserum by delipidation and defibrination
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody at 2 °C to 8 °C up to one month or (in aliquots) at -20 °C to -70 °C for longer. Avoid repeated freezing and thawing. Centrifuge product if not completely clear after standing at room temperature.
Gene Name	class II, major histocompatibility complex, transactivator
Database Link	Entrez Gene 4261 Human UniProt ID P33076
Background	The transactivator CIITA regulates basal and interferon-induced expression of MHC class II genes. CIITA restores expression of all MHC II gene expression in mutant cells and corrects regulatory defects of those genes. Activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. CIITA may act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter.
Synonyms	MHC2TA
Reference Data

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.