SIRT7 (35-51, 361-377) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Immunohistochemistry on Paraffin Sections: 5 µg/ml. Western Blot: 1 - 3 µg/ml.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	A mixture of synthetic peptides corresponding to amino acids 35-51 and 361-377 of human SIRT7.
Specificity	This antibody recognizes Sirtuin Type 7 (SIRT7).
Formulation	PBS containing 0.2% Gelatin as stabilizer and 0.05% Sodium Azide as preservative. State: Aff - Purified State: Liquid purified Ig fraction.
Concentration	lot specific
Purification	Protein G Chromatography.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	sirtuin 7
Database Link	Entrez Gene 51547 Human UniProt ID Q9NRC8
Background	SIRT7 is a human member of a family of proteins called Sirtuins (Sir2-like proteins) and are present in prokaryotes and eukaryotes. All Sir2-like proteins have a sirtuin core domain, which contains a series of sequence motifs conserved in organisms ranging from bacteria to humans. Bacterial, yeast and mammalian sirtuins are able to metabolize NAD and possibly at as mono-ADP-ribosyltransferases. The enzymatic function of sirtuins is not yet completely understood but recent reports of histone-activated Sir2-mediated NAD metabolism and NAD-activated Sir2-mediated histone deacetylation suggest a possible coupled reciprocal activation mechanism involving interactions of Sir2 with NAD and the N epsilon-acetyl-lysine groups of acetylated histones.
Synonyms	SIRT-7, SIR2-like protein 7, SIR2L7, sirtuin type 7, sirtuin 7, sirtuin-7
Reference Data

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