Dopamine Transporter (SLC6A3) (N-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC, WB
Recommend Dilution	ELISA: 1 µg/ml. Immunohistochemistry on Paraffin Sections: 20 µg/ml. Western Blot: 1 µg/ml.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to N-terminal residues of Human DAT (Sodium-dependent Dopamine Transporter).
Specificity	This antibody recognizes SLC6A3/DAT1 (N-term).
Formulation	PBS containing 0.01% Sodium Azide as preservative and 50% Glycerol as stabilizer. State: Aff - Purified State: Liquid purified Ig fraction.
Concentration	lot specific
Purification	Immunoaffinity Chromatography.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Gene Name	solute carrier family 6 member 3
Database Link	Entrez Gene 6531 Human UniProt ID Q01959
Background	Plasmalemmal neurotransmitter transporters sequester synaptic and peri synaptic transmitter into presynaptic elements. The Dopamine Transporter (DAT) is responsible for the reaccumulation of dopamine after it has been released. Levels of DAT protein expression are altered by chronic drug administration. The activity of the DAT reuptake carrier is sodium dependent, and it is suspected to play a role in such neurologic and psychiatric disorders as Parkinson's disease, Tourette's disease, schizophrenia, and addiction. It is a 12 transmembrane domain transporter with the N and C terminal regions located within the cytoplasm.
Synonyms	Sodium-dependent dopamine transporter, DA transporter, DAT1
Note	Predicted Molecular Weight: 68 kDa.
Reference Data

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