Hepatitis B Core Antigen / HBcAg Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC
Recommend Dilution	Immunohistochemistry for Formalin-Fixed Paraffin Embedded (FFPE) Tissue Sections and Frozen Sections: Dilute 1/200-1/400 using polymer or streptavidin ~biotin system for 30 mins at room temperature. Positive control: Human liver infected with hepatitis B virus.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Purified hepatitis B core antigen.
Specificity	Antibody to hepatitis B core antigen (anti-HBc) is considered a sensitive and specific serum marker of hepatitis B virus(HBV) infection. Cellular localization: Hepatocyte nuclei.
Formulation	10 mM PO4, 150 mM NaCl, pH 7.4 containing 0.05% Sodium Azide as preservative. State: Ig Fraction State: Total Ig fraction.
Concentration	lot specific
Purification	Protein A
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Background	Hepatitis B Virus Core Antigen (HBcAg) is part of the infectious virion containing an inner "core particle" enclosing the viral genome. The icosahedral core particle contains 180 or 240 copies of the core protein. HBcAg is one of the three major clinical antigens of hepatitis B virus but disappears early in the course of infection. The hepatitis B virus core antigen (HBcAg) is a highly immunogenic subviral particle and functions as both a T-cell-dependent and a T-cell-independent antigen. Therefore, HBcAg may be a promising candidate target for therapeutic vaccine control of chronic HBV infection.
Synonyms	HBV Capsid protein, HBV Core protein, p21.5
Reference Data

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