MAP1 (MOAP1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Immunohistochemistry on Paraffin Sections: 2.5 µg/ml. Western Blot: 1 µg/ml.
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic Peptide corresponding to 15 amino acid peptide from near the center of human MAP-1.
Specificity	This antibody recognises MAP-1 Protein (MOAP1).
Formulation	Phosphate Buffered Saline PBS containing 0.02% Sodium Azide as preservative. State: Aff - Purified State: Liquid purified IgG fraction.
Concentration	lot specific
Purification	Immunoaffinity Chromatography.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C to -70°C for longer. Dilute only prior to immediate use. Avoid repeated freezing and thawing.
Gene Name	modulator of apoptosis 1
Database Link	Entrez Gene 64112 Human UniProt ID Q96BY2
Background	Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Members of the Bcl-2 family are known to be critical regulators of this process. These proteins are characterized by the presence of several conserved motifs termed Bcl-2 homology (BH) domains. A related protein termed MAP-1 has recently been identified. This protein contains a BH3-like domain and induces caspase-dependent apoptosis in mammalian cells when overexpressed. It forms homodimers and associates with Bcl-2 family members such as Bax, Bcl-2, and Bcl-XL in vitro and in vivo. It has been suggested that MAP-1 associates with the tumor suppressor RASSF1A following death receptor activation, allowing a conformational change in Bax that leads to cellular apoptosis.
Synonyms	MAP-1, MAP1, Modulator of apoptosis 1
Reference Data

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