Angiotensin Converting Enzyme 2 (ACE2) Rabbit Polyclonal Antibody

CAT#: AP07652PU-N

Angiotensin Converting Enzyme 2 (ACE2) rabbit polyclonal antibody, Aff - Purified



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CNY 6,721.00


货期*
5周

规格
    • 50 ug

Product images

Specifications

Product Data
Applications IHC, WB
Recommend Dilution Immunohistochemistry on Paraffin Sections: 2.5 µg/ml.
Western Blot: 0.5 - 2 µg/ml.
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Immunogen Synthetic peptide corresponding to amino acids near the center of human ACE2. The immunogen is located within aa 180-230 of ACE2.
Specificity This antibody reacts with a peptide corresponding to amino acids near the center of ACE2.
Formulation PBS containing 0.02% Sodium Azide as preservative.
State: Aff - Purified
State: Liquid purified IgG fraction.
Concentration lot specific
Purification Immunoaffinity Chromatography.
Conjugation Unconjugated
Storage Condition Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C to -70°C for longer.
Avoid repeated freezing and thawing.
Gene Name angiotensin I converting enzyme 2
Background Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology . In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. Recently, ACE2 has also been shown to be a functional receptor of the SARS coronavirus. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function.
Synonyms Angiotensin-converting enzyme 2
Note Family: Protease.
Subfamily: Metallopeptidase M2.
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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