IL1 Receptor II (IL1R2) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IF, IHC, IP, WB
Recommend Dilution	ELISA. Immunofluorescence. Immunohistochemistry on Paraffin Sections: 10 µg/ml. Immunoprecipitation. Western Blot.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant Human IL-1R type II.
Specificity	Recognizes CD121b / IL1R2.
Formulation	0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 with 0.01% (w/v) Sodium Azide as preserevative. State: Purified State: Liquid purified IgG fraction.
Concentration	lot specific
Purification	Protein A Chromatography.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	interleukin 1 receptor type 2
Database Link	Entrez Gene 7850 Human UniProt ID P27930
Background	CDw121b is a 65 kD member of the immunoglobulin superfamily also known as IL-1 receptor (IL-1R) type II. The IL-1R family is composed of three proteins: IL-1R type I, IL-1R type II, and the widely expressed IL-1R AcP. Both IL-1R type I and type II bind IL-1 alpha and IL-1 beta, although with differing affinities. The high affinity complex consists of IL-1R type I and IL-1R AcP, whereas IL-1 binds to IL-1R type II with low affinity. The IL-1 receptor antagonist (IL-1RA) can bind to both IL-1R type I and II. IL-1R type II is expressed at low levels on B cells, monocytes/macrophages, neutrophils, basal epithelia of the skin, and T cells. Binding of IL-1 to the high affinity IL-1 receptor mediates thymocyte and T cell activation, fibroblast proliferation, and induction of acute phase protein production. Binding of IL-1 to CDw121b appears to be dispensable for IL-1 signaling and may negatively regulate IL-1 responses acting as a quotdecoy quot receptor.
Synonyms	Interleukin-1 receptor type II, IL-1R-2, IL-1R-beta, CDw121b, IL1RB
Reference Data

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