MAVS Rabbit Polyclonal Antibody
CAT#: AP07387PU-N
MAVS rabbit polyclonal antibody, Aff - Purified
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CNY 5,511.00
货期*
5周
规格
Specifications
Product Data | |
Applications | IHC, WB |
Recommend Dilution | Immunohistochemistry on Paraffin Sections: 5 µg/ml. Western Blot: 0.5 - 2 µg/ml. |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Synthetic peptide |
Specificity | This antibody reacts to a 17 amino acid peptide from near the center of VISA. |
Formulation | Phosphate buffered saline, containing 0.02% sodium azide State: Aff - Purified State: Liquid purified Ig |
Concentration | lot specific |
Purification | Immunoaffinity Chromatography |
Conjugation | Unconjugated |
Storage Condition | Store the antibody undiluted at 2-8°C. DO NOT FREEZE! |
Gene Name | mitochondrial antiviral signaling protein |
Database Link | |
Background | Double-stranded RNA viruses are recognized in a cell type-dependent manner by the transmembrane receptor TLR3 (MIM 603029) or by the cytoplasmic RNA helicases MDA5 (MIM 606951) and RIGI (ROBO3; MIM 608630). These interactions initiate signaling pathways that differ in their initial steps but converge in the activation of the protein kinases IKKA (CHUK; MIM 600664) and IKKB (IKBKB; MIM 603258), which activate NFKB (see MIM 164011), or TBK1 (MIM 604834) and IKKE (IKBKE; MIM 605048), which activate IRF3 (MIM 603734). Activated IRF3 and NFKB induce transcription of IFNB (IFNB1; MIM 147640). For the TLR3 pathway, the intermediary molecule before the pathways converge is the cytoplasmic protein TRIF (TICAM1; MIM 607601). For RIGI, the intermediary protein is mitochondria-bound IPS1 (Sen and Sarkar, 2005). |
Synonyms | IPS1, VISA, Mitochondrial antiviral-signaling protein, Cardif, Virus-induced-signaling adapter, CARD adapter inducing interferon-beta |
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