TNFRSF14 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	Immunocytochemistry. Immunohistochemistry on Paraffin Sections: 5 µg/ml. Western Blot: 2 µg/ml.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide
Specificity	This antibody reacts to a 16 amino acid peptide from near the carboxy terminus of TNFRSF14.
Formulation	Phosphate buffered saline, containing 0.02% sodium azide State: Aff - Purified State: Liquid purified Ig
Concentration	lot specific
Purification	Immunoaffinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C. DO NOT FREEZE!
Gene Name	tumor necrosis factor receptor superfamily member 14
Database Link	Entrez Gene 8764 Human UniProt ID Q92956
Background	HVEM (Herpes virus entry mediator) is a member of the tumor necrosis factor receptor family. This family of receptors plays a central role in the development of the immune system. HVEM has been shown to mediate HSV entry into activated T cells, in addition to modulating the activation of nuclear factor NF-kB (a transcriptional activator of multiple immuno modulatory and inflammatory genes) and transcription factor AP-1 (a regulator of cellular stress-response genes). Binding by HVEM of the ligand LIGHT induces receptor down regulation. Degradation or release of LIGHT by matrix metalloproteinases then contributes to the return to baseline levels for both LIGHT and HVEM.
Synonyms	HVEA, Herpesvirus entry mediator A, TR2
Reference Data

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