GPR37 (N-term extracell. dom.) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, IHC
Recommend Dilution	ELISA. Immunohistochemistry on Paraffin Sections: 3 µg/ml.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	GPR37 antibody was raised against synthetic 20 amino acid peptide from N-terminal extracellular domain of human GPR37.
Specificity	This antibody detects N-terminal extracellular domain of human PAEL Receptor (GPR37).
Formulation	PBS containing 0.09% sodium azide as preservative State: Aff - Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Immunoaffinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C to -70°C for longer. Avoid repeated freezing and thawing.
Gene Name	G protein-coupled receptor 37
Database Link	Entrez Gene 2861 Human UniProt ID O15354
Background	GPR37 is an Orphan-A GPCR with an unknown ligand. GPR37 was recently identified as the PAEL receptor, a Parkin substrate involved in autosomal recessive juvenile Parkinson's (PDJ) disease. The PAEL receptor becomes unfolded, insoluble, and ubiquitinated when overexpressed, leading to unfolded protein-induced cell death. When the PAEL receptor is ubiquitinated by Parkin, it gets degraded, resulting in the suppression of cell death. The insoluble form of the PAEL receptor accumulates in the brains of PDJ patients and may cause selective neuronal death.
Synonyms	G-protein coupled receptor 37, PAELR, ETBR-LP-1
Reference Data

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