CABLES1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	Western blot: 1/500-1/1000. Immunohistochemistry on paraffin sections: 1/50-1/200. Immunofluorescence: 1/50-1/200.
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide, corresponding to amino acids 550-600 of Human Cables1.
Specificity	This antibody detects endogenous levels of Cables1 protein. (region surrounding Lys588)
Formulation	Phosphate buffered saline (PBS), pH 7.2 with 0.02% Sodium Azide, 50% Glycerol
Concentration	1.0 mg/ml
Purification	Affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE)
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	~ 67 kDa
Gene Name	Cdk5 and Abl enzyme substrate 1
Database Link	Entrez Gene 91768 Human UniProt ID Q8TDN4
Background	Normal Abl function is essential for humans because Philadelphia chromosome translocation involving the ABL gene causes chronic myelogenous leukemia. Abl associates with a broad range of targets and appears to function in various signaling pathways. Cables, a 568 amino-acid protein, links Abl to cyclin-dependent kinase 5 (Cdk5). Cables bound to Cdk5 functions as a substrate for phosphorylation by the Cdk5/p35 kinase. Cables contains an area of weak homology to cyclin A and cyclin C. In addition to its C-terminal Cdk5 binding domain, Cables also has six potential SH3 binding motifs (PXXP) clustered around the amino terminus, two of which are similar to motifs known to bind the Abl SH3 domain. Cables forms a trimolecular complexwith Cdk5 and Abl in vivo. All three proteins colocalize within cortical axons, particularly in their growth cones. Cables and Abl may function as adaptor or scaffolding proteins to bind to Cdk5 and control its subcellular location in the neuron.
Synonyms	Ik3-1
Reference Data

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