gamma Tubulin (TUBG1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Western blot: 1/500-1/1000. Immunohistochemistry on Paraffin Sections: 1/50-1/200.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide, corresponding to amino acids 380-430 of Human Tubulin γ.
Specificity	Tubulin gamma antibody detects endogenous levels of Tubulin gamma protein. (region surrounding Phe414)
Formulation	Phosphate buffered saline (PBS), pH~7.2 State: Aff - Purified State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE). Preservative: 15 mM Sodium Azide
Concentration	1.0 mg/ml
Purification	Affinity Chromatography using epitope-specific immunogen.
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	~ 51 kDa
Gene Name	tubulin gamma 1
Database Link	Entrez Gene 103733 MouseEntrez Gene 252921 RatEntrez Gene 7283 Human UniProt ID P23258
Background	TUB4, the gene for Saccharomyces cerevisiae gamma-Tubulin, encodes a 473 amino acid structural protein that localizes to the spindle pole body. gamma Tubulin, an essential protein for cell growth, organizes microtubule arrays in the nucleus and cytoplasm. gamma Tubulin-depleted cells fail to form functional spindles and arrest during nuclear division. gamma Tubulin associates with spindle body components Spc97 and Spc98 to form the gamma Tubulin complex. The budding yeast gamma Tubulin complex contains one molecule each of Spc97 and Spc98 and two molecules of gamma Tubulin. In the SPB, Spc110 binds Spc97 and Spc98 of the gamma Tubulin complex. 2D gel analysis indicates five isoforms of gamma Tubulin. The phosphorylation of gamma Tubulin at Tyr 445 plays a regulatory role in microtubule formation. The incidence rate for this phosphorylation event peaks during G1.
Synonyms	Tubulin gamma-1 chain, Gamma-1-tubulin, GCP-1
Reference Data
Protein Families	Druggable Genome

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