NM23A (NME1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	Western blot: 1/500-1/1000.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide, corresponding to amino acids 87-130 of Human NM23-H2.
Specificity	This antibody detects endogenous levels of NM23/NDP Kinase B protein. (region surrounding His118)
Formulation	Phosphate buffered saline (PBS), pH 7.2. State: Aff - Purified State: Liquid purified Ig fraction Preservative: 0.05% sodium azide
Concentration	1.0 mg/ml
Purification	Affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE)
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	~ 23 kDa
Gene Name	NME/NM23 nucleoside diphosphate kinase 1
Database Link	Entrez Gene 18102 MouseEntrez Gene 191575 RatEntrez Gene 4830 Human UniProt ID P15531
Background	The nm23 protein is the collective designation for two closely related proteins encoded by the genes nm23H1 and nm23H2 now called NME1 and NME2. The protein is expressed in the nucleus and cytoplasm of all normal cells, and on the cell surface of many haematopoietic cells, including erythrocytes. Tumour cells with a high metastatic potential often lack or express only a low amount of nm23 protein, hence the nm23 protein has been described as a metastasis suppressor protein. Recent studies, however, suggest a more complex relationship between occurrence of the nm23 protein and metastatic activity.
Synonyms	NM23
Reference Data
Protein Families	Druggable Genome, Stem cell - Pluripotency
Protein Pathways	Metabolic pathways, Purine metabolism, Pyrimidine metabolism

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