p53 (TP53) Rabbit Polyclonal Antibody
CAT#: AP06266PU-N
p53 (TP53) rabbit polyclonal antibody, Aff - Purified
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CNY 4,640.00
货期*
2周
规格
Cited in 1 publication. |
Specifications
Product Data | |
Applications | IHC, WB |
Recommend Dilution | Western blot: 1/500-1/1000. Immunohistochemistry on paraffin sections: 1/50-1/200. |
Reactivity | Human, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Synthetic peptide, corresponding to the N-terminus of Human p53. |
Specificity | This antibody detects endogenous levels of p53 protein. (region surrounding Ser9) |
Formulation | PBS, pH~7.2 State: Aff - Purified State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE). Preservative: 15 mM Sodium Azide |
Concentration | 1.0 mg/ml |
Purification | Affinity Chromatography using epitope-specific immunogen |
Conjugation | Unconjugated |
Storage Condition | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Predicted Protein Size | ~53,43 kDa |
Gene Name | tumor protein p53 |
Database Link | |
Background | p53 is a DNA-binding, oligomerization domain and transcription activation domain-containing tumor suppressor that upregulates growth arrest and apoptosis-related genes in response to stress signals, thereby influencing programmed cell death, cell differentiation and cell cycle control mechanisms. p53 localizes to the nucleus yet can be chaperoned to the cytoplasm by the negative regulator MDM2, an E3 ubiquitin ligase that is upregulated in the presence of active p53, where MDM2 polyubiquitinates p53 for proteasome targeting. p53 can assemble into tetramers in the absence of DNA, fluctuates between latent and active (DNA-binding) conformations, and is differentially activated through posttranslational modifications including phosphorylation and acetylation. Mutations in the DNA-binding domain (DBD) (amino acids 110-286) of p53 can compromise energetically favorable association with cis elements and are implicated in several human cancers. |
Synonyms | Cellular tumor antigen p53, Tumor suppressor p53, Phosphoprotein p53, NY-CO-13 |
Reference Data |
Citations (1)
The use of this Antibodies has been cited in the following citations: |
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Inhibition of p22phox Suppresses Epithelial Ovarian Cancer Cell Proliferation and Tumorigenesis
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Journal of Cancer
,PubMed ID 34093828
[TP53]
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