FAIM3 (FCMR) (C-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	Western Blot: 1-2 µg/ml.
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	A 13 amino acid peptide from near the carboxy terminus of Human Toso.
Specificity	This antibody detects an epitope within the C-terminal (CT) region of Human Toso, also known as Fas Apoptotic Inhibitory Molecule 3 (FAIM3). In Western Bloting, This antibody detects a band of approximately 43kDa in Human lung tissue lysate.
Formulation	PBS State: Purified State: Liquid purified IgG fraction Preservative: 0.02% Sodium Azide
Concentration	lot specific
Purification	Affinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	Fc fragment of IgM receptor
Database Link	Entrez Gene 9214 Human UniProt ID O60667
Background	Toso is expressed by lymphoid and haematopoietic cells and is up-regulated by T-cell activation. Toso expressing cells have increased resistance to Fas-, FADD-, and TNFalpha-induced apoptosis. Toso is membrane bound, and is thought to directly bind to FADD, disrupting DISC formation and thus inhibiting caspase-8 activation. Toso is a potential proto-oncogene, and could be a therapeutic target for use in the treatment of autoimmune diseases. Despite its predicted molecular weight, Toso often migrates at 60kDa in SDS PAGE.
Reference Data

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